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■ Two New Isoflavonoids and a New 2-Arylbenzofuran from the Roots of Erythrina variegata

Hitoshi Tanaka,* Masaru Sudo, Miyuki Hirata, Magoichi Sako, Masaru Sato, Ih-Sheng Chen, and Toshio Fukai

*Faculty of Pharmacy, Meijo University, Yagoto, Tempaku-ku, Nagoya 468-8503, Japan

Abstract

Two new isoflavonoids, eryvarins S (1) and T (2), and a new 2-arylbenzofuran, eryvarin U (3), together with nine known compounds, were isolated from the roots of Erythrina variegata. Their structures were established on the basis of spectroscopic analysis. Eryvarin U is a rare naturally-occurring 2-arylbenzofuran. The antibacterial activity of these three new compounds against 13 strains of methicillin-resistant Staphylococcus aureus (MRSA) was examined in which eryvarin U showed the highest antibacterial activity.