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Communication | Special issue | Vol 67, No. 1, 2006, pp.75-78
Published online, 28th February, 2005
DOI: 10.3987/COM-04-S(T)2
Direct Comparison of SN2 Mesylate Displacement versus the Mitsunobu Protocol for 2’,3’-Dideoxyspirocarbanucleoside Construction

Ryan E. Hartung and Leo A. Paquette*

*Evans Chemical Laboratories, The Ohio State University, 120 W. 18th Avenue, Columbus, Ohio 43210, U.S.A.


The two title reactions have been evaluated in order to maximize the efficiency with which pyrimidine and purine nucleobases can be introduced into 2’,3’-dideoxyspirocarbanucleosides.