Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 64, No. 1, 2004, pp.65-74
Published online, 9th November, 2004
DOI: 10.3987/COM-04-S(P)45
Polyhydroxyazepanes Mimicking Monosaccharides: Synthesis of an α-D-Galacto-like Iminoheptitol

Hongqing Li, Yves Blériot,* Jean-Maurice Mallet, Yongmin Zhang, Eliazar Rodriguez-Garcia, Pierre Vogel, Silvia Mari, Jesús Jiménez-Barbero, and Pierre Sinaÿ*

*Chemistry Department, UMR 8642, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 05, France

Abstract

The synthesis of three new examples of seven-membered ring iminoalditols, displaying an extra hydroxymethyl group on the ring compared to the previously reported polyhydroxylated azepanes, has been achieved from D-lyxonolactone. None of them, including the α-D-galacto-like azepane (7), showed significant glycosidase inhibition on green coffee bean α-galactosidase and other commercially available hydrolases.