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Communication | Special issue | Vol 64, No. 1, 2004, pp.27-31
Published online, 3rd August, 2004
DOI: 10.3987/COM-04-S(P)16
Synthesis of Bicyclic Heterocycles from Propargyl Esters Using a Palladium Catalyst Bearing a Bidentate Ligand

Masaya Tsubakiyama, Yoshihiro Sato, and Miwako Mori*

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan


A method for synthesis of bicyclic heterocycles having functional group was developed from phenylpropargyl esters using a palladium catalyst and bidentate ligand. Isoquinoline and benzoazepine derivatives having functional groups could be synthesized using this method in high yields.