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Note | Regular issue | Vol 65, No. 3, 2005, pp.643-647
Published online, 28th January, 2005
DOI: 10.3987/COM-04-10286
A Phosphino-substituted Isoindole Obtained by Cyclization of a Thiourea Derivative

Jorge R. Angulo-Cornejo, Arancha Carbayo, Elva Cueva-Talledo, José V. Cuevas, Gabriel García-Herbosa,* and Asunción Muñoz

*Area of Inorganic Chemistry, Faculty of Sciences, University of Burgos, Misael Bañuelos Square, 09001 Burgos, Spain

Abstract

A phosphorous functionalized isoindole derivative has been formed in the cyclization reaction of 3-chloro-p-tolylmethylene-1,1-diethylthiourea with lithium diphenylphosphide. The reaction involves thiourea desulfuration and C-S to P-S sulfur transfer.