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Paper | Regular issue | Vol 65, No. 2, 2005, pp.337-343
Published online, 24th December, 2004
DOI: 10.3987/COM-04-10285
Efficient Synthesis of New Potentially Bioactive Tricyclic Pyridinones

Caroline Cstera, Maxime D. Crozet, Michel P. Crozet, and Patrice Vanelle*

*Laboratory of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, CNRS UMR, University of the Méditerranée (Aix-Marseille 2), 27 Boulevard Jean Moulin, 13385 Marseille cedex 5, France

Abstract

A rapid synthetic route towards new tricyclic pyridinones, from 6-halogeno-3-nitroimidazo[1,2-a]pyridines bearing the diethyl methylenemalonate group at the 2-position or directly from 6-halogeno-3-nitroimidazo[1,2-a]pyridines bearing the diethyl methylmalonate group at the 2-position, is described.