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Note | Regular issue | Vol 65, No. 3, 2005, pp.637-642
Published online, 1st February, 2005
DOI: 10.3987/COM-04-10270
A Synthesis and Reactivity of 1,4-Dihydro-4-thioxo-3-quinolinesulfonamides

Leszek Skrzypek

*Department of Organic Chemistry, The Medical University of Silesia, Jagiellonska 4, 41-200 Sosnowiec, Poland


4-Chloro-3-quinolinesulfonamides (1) were transformed to 1,4-dihydro- 4-thioxo-3-quinolinesulfonamides (2) which methylation gave 4-methylthio-3-quinolinesulfonamides (3). Oxidation of sulfonamides (2) with hydrogen peroxide provided 1,4-dihydro-4-oxo-3-quinolinesulfonamides (4).