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Paper | Regular issue | Vol 65, No. 2, 2005, pp.293-301
Published online, 17th December, 2004
DOI: 10.3987/COM-04-10258
Synthesis of the Amidite Reagent to Built Bipyridine Units into DNA Backbone

Toshihiro Ihara,* Yoshinori Shirasaka, Yoshinobu Sato, Yusuke Kitamura, Kenji Okada, Masato Tazaki, and Akinori Jyo

*Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kumamoto University, Kurokami 2-39-1, Kumamoto 860-8555, Japan


A new amidite reagent (9) containing 6,6’-bis(acylamino)-2,2’- bipyridine unit was synthesized in moderate yields by a dependable eight step procedure. The unit should work as a metal ion-directed conformational modulator when it is built into the backbone of synthetic DNAs.