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Paper | Regular issue | Vol 65, No. 2, 2005, pp.287-291
Published online, 3rd December, 2004
DOI: 10.3987/COM-04-10240
The Sesquiterpenoids from Cynara scolymus

Xiaoli Li, Pingli Qian, Zeyuan Liu, Yu Zhao, Gang Xu, Deding Tao, Qinshi Zhao,* and Handong Sun

*State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650204, Yunnan, China

Abstract

Two new guaiane-type sesquiterpene lactones, cynarinins A (1) and B (2), together with seven known compounds, cynarascoloside C (3), cynaropicrin (4), aguerin B (5), grosheimin (6), dehydrocynaropicrin (7), aguerin A (8) and cynartriol (9), were isolated from aerial part of Cynara scolymus. The structures of new compounds were elucidated by means of 1D NMR, 2D NMR and HRMS spectral analysis. Cynaropicrin (4) and grosheimin (6) showed weak cytotoxicity against MCF-7 cancer cell line, and other compounds had no obvious activity against the same cell line.