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Note | Regular issue | Vol 65, No. 2, 2005, pp.359-364
Published online, 17th December, 2004
DOI: 10.3987/COM-04-10236
Synthesis and Characterization of a New Series of 3-(4-Antipyrinyl)-2-thiohydantoin Derivatives

Chun-Ming Ma, Jian-Ping Li,* and Peng-Zhi Zheng

*College of Chemistry and Environmental Science, Henan Normal University, Xinxiang, 453007, Henan, China

Abstract

This paper reports the reaction of 4-antipyrinyl isothiocyanate with DL-amino acids affording a new heterocyclic series of 3-(4-antipyrinyl)-2-thiohydantoin derivatives in mild conditions. The reaction proves to be simple and the experiment is easy to operate with high yields (86-96%).