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Paper | Regular issue | Vol 63, No. 12, 2004, pp.2805-2812
Published online, 26th October, 2004
DOI: 10.3987/COM-04-10231
Facile Synthesis of 5-Acyl-2-amino-1,3-thiazole by the Reaction of Thiaazadienes with α-Haloketones

Ramadas Sathunuru and Ed Biehl*

*Chemistry Department, Southern Methodist University, Dallas, TX 75275-0314, U.S.A.


The reaction of thiaazadienes (1a–e) with α-halo ketones (2a–d) gives 5-acyl-2-amino-1,3-thiazole (3a–q) in high yields.