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Paper | Regular issue | Vol 65, No. 1, 2005, pp.49-58
Published online, 16th November, 2004
DOI: 10.3987/COM-04-10209
Synthesis and Structure of New Heterocyclic Derivatives of Curcumin

M. Concepción Lozada, Raúl G. Enríquez,* Carlos E. Lobato, Benjamín Ortíz, Manuel Soriano, Dino Gnecco, and William F. Reynolds

*Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Mexico


New heterocyclic derivatives of curcumin (3) of different ring size were synthesized by reaction of a key intermediate, 1,7-bis(4-acetoxy-3-methoxyphenyl)hepta-3,5-dione (5) with some bi-nucleophilic molecules. These new synthetic derivatives were obtained in good yields and the structure of all compounds was supported by MS, IR, 1D and 2D 1H and 13C NMR spectra and elemental analysis.