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Paper | Regular issue | Vol 63, No. 11, 2004, pp.2581-2589
Published online, 22nd September, 2004
DOI: 10.3987/COM-04-10207
The Absolute Structures of Dihydroepiheveadride, as Characteristic Antifungal Agent against Filamentous Fungi, and Its Related Compounds from Unidentified Fungus IFM 52672

Tomoo Hosoe, Kazutaka Fukushima, Takeshi Itabashi, Koohei Nozawa, Kayoko Takizawa, and Ken-ichi Kawai*

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan


A new nonadride derivative, deoxoepiheveadride (2), was isolated along with dihydroepiheveadride (1), as a characteristic antifungal agent, from unidentified fungus IFM 52672. The absolute structures of 1 and 2 were elucidated by the spectroscopic and chemical investigation. The absolute configuration of heveadride (4), which had been isolated from Bipolaris heveae CBS 241.93, was also determined by X-Ray crystallographic analysis.