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Paper | Regular issue | Vol 63, No. 10, 2004, pp.2355-2362
Published online, 27th August, 2004
DOI: 10.3987/COM-04-10196
Synthesis of Cribrostatin 6

Shinsuke Nakahara* and Akinori Kubo

*Meiji Pharmaceutical University, 2-552-1, Noshio, Kiyose, Tokyo 204-8588, Japan


The first synthesis of cribrostatin 6 (1), a dark blue cancer cell growth inhibiter was achieved in ten-steps from 2,4-diethoxy-3-methylphenol (8), utilizing a catalytic hydrogenation which induces an intramolecular transfer reaction.