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Paper | Regular issue | Vol 63, No. 11, 2004, pp.2515-2522
Published online, 8th September, 2004
DOI: 10.3987/COM-04-10172
A General and Efficient Method for Synthesis of Functionalized Ethylenediamine Derivatives

Donghong Li, Junsheng Hao, Wei Guo,* and Chizhong Xia*

*School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China


Reaction of tetrahydrofolate model, 1-tosyl-3,4-dimethylimidazolinium iodide (1), and a series of aromatic or aliphatic amines produced N,N,N’-trisubstituted-2-methylethylenediamine derivatives (2-10) in good to excellent yields through a nucleophilic addition and the followed ring-opening mechanism. The coenzyme model was proved to be more electrophilic than those reported before.