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Paper | Regular issue | Vol 63, No. 8, 2004, pp.1849-1854
Published online, 21st June, 2004
DOI: 10.3987/COM-04-10126
Synthesis of Minosamycin and 5,8-Dihydroxy-4,7-dimethloxy-2,6-dimethylisoquinolinium Iodide

Shinsuke Nakahara* and Akinori Kubo

*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan


The one-pot synthesis of mimosamycin utilizing the Polonovski reaction and a five-step synthesis of 5,8-dihydroxy-4,7-dimethoxy-2,6-dimethylisoquinolinium iodide (7) from known compound (8) are described.