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Note | Regular issue | Vol 63, No. 9, 2004, pp.2071-2077
Published online, 16th July, 2004
DOI: 10.3987/COM-04-10124
Synthesis of 5-Benzoyl-6-trifluoromethyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic Acid

Adrián Covarrubias Zúñiga

*Institute of Chemistry, Autonomous National University of México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, Mexico


Synthesis of the possible analgesic and/or antiinflammatory agent 5-benzoyl-6-trifluoromethyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (1) was designed from the already known intermediate ester 3-methoxycarbonyl-4-trifluoromethyl-5-benzyloxycarbonylpyrrole-2-acetic acid methyl ester (4) wich is prepared via a Knorr synthesis.