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■ Novel 3-Aminothieno[2,3-b]pyridine Synthesis via a Silicon-directed Anionic Cyclization

Jason S. Parnes* and Mercedes Delgado

*Department of Medicinal Chemistry, Signal Pharmaceuticals, LLC, 4550 Towne Center Ct., San Diego, CA 92121, U.S.A.

Abstract

A novel strategy yielding a 3-aminothiophene is described herein. This specifically relies upon an α-thiomethylsilane directing deprotonation, thereafter cyclization of the resultant anion into a pendant nitrile forms the necessary 3-aminothiophene ring.