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Paper | Special issue | Vol 64, No. 1, 2004, pp.177-191
Published online, 25th June, 2004
DOI: 10.3987/COM-04-10118
Solvent-free Synthesis of Quinolones Derivatives

Petra Cernuchová, Giang Vo-Thanh, Viktor Milata*, and André Loupy*

*Laboratoire des Réactions Sélectives sur Supports, ICMMO, CNRS UMR 8615, Bât. 410, Université Paris-Sud, Orsay 91405, Orsay Cedex, France

Abstract

Quinolones can be prepared in a three step procedure from triethylorthoformate and activated methylene derivatives leading to alkoxymethylenemalonates followed by reaction with aromatic amines and finally a cyclization. All the reactions were carried out under solvent-free conditions possibly under microwave activation with benefits for the first step.