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Communication | Regular issue | Vol 63, No. 8, 2004, pp.1757-1763
Published online, 1st June, 2004
DOI: 10.3987/COM-04-10097
A New Method for Regioselective Synthesis of a Broad-Spectrum Parenteral S-3578-Related Cephalosporin Bearing an Imidazo[4,5-b]pyridinium Derivative at C-3

Hidenori Yoshizawa, Katsuki Yokoo, Takashi Nomura, Takafumi Ohara, Koji Ishikura,* and Yasuhiro Nishitani

*Shionogi Rresearch Laboratories, Shionogi & Co. Ltd., Fukushima-ku, Osaka 553-0002, Japan


A broad-spectrum S-3578-related cephalosporin, 7β-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-fluoromethoxyiminoacetamido]-3-[1-(3-methylamino-propyl)-1H-imidazo[4,5-b]pyridinium-4-yl]methyl-3-cephem-4-carboxylate sulfate was regioselectively synthesized in a good yield using diaminopyridine derivative bearing a dimethylformamidine group.