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Note | Regular issue | Vol 63, No. 6, 2004, pp.1443-1448
Published online, 9th April, 2004
DOI: 10.3987/COM-04-10062
A Bioactive Alkaloid from the Flowers of Trollius chinensis

Ru Feng Wang, Xiu Wei Yang, Chao Mei Ma, Shao Qing Cai,* Jian Nong Li, and Yukihiro Shoyama

*Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China


A new compound, named as trolline was isolated from the ethanol extract of the flowers of Trollius chinensis Bunge. The chemical structure of this compound was elucidated by NMR, MS, IR, UV spectra and single-crystal X-Ray analysis. The in vitro antibacterial and antiviral experiments revealed that trolline exhibited appreciable antibacterial activity against respiratory bacteria such as Staphylococcus aureus, Streptococcus pneumoniae and Klebsiella pneumoniae. Trolline was also demonstrated to have moderate antiviral activity against influenza virus A and B.