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Paper | Regular issue | Vol 63, No. 5, 2004, pp.1131-1142
Published online, 26th March, 2004
DOI: 10.3987/COM-04-10041
Synthesis of Isotope Labeled Me(3a)-13C-Physostigmine and Debromoflustramine B

Martha S. Morales-Ríos,* Norma F. Santos-Sánchez, Yolanda Mora-Pérez, and Pedro Joseph-Nathan

*Departamento de Química, Centro de Investigación y de Estudios Avanzados, I.P.N, Apartado 14-740, México, D.F., 07000, Mexico


A versatile and concise synthetic route for the synthesis of selectively functionalized pyrrolo[2,3-b]indole alkaloid analogues has been developed starting from 3-indolylacetonitriles. Employing this route, physostigmine with 13C-enrichment at Me(3a) (99 atom% 13C) and debromoflustramine B have been prepared.