Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 63, No. 5, 2004, pp.1123-1129
Published online, 30th March, 2004
DOI: 10.3987/COM-04-10037
Gliocladins A - C and Glioperazine ; Cytotoxic Dioxo- or Trioxopiperazine Metabolites from a Gliocladium Sp. Separated from a Sea Hare

Yoshihide Usami,* Junko Yamaguchi, and Atsushi Numata

*Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan


New dioxo- or trioxopiperazine metabolites named gliocladins A-C (1 - 3) and glioperazine (4) have been isolated from a strain of Gliocladium sp., originally separated from the sea hare. Their structures have been elucidated by spectroscopic analyses using various NMR spectroscopic techniques. Structurally unique trioxopiperazine (3) exhibited significant cytotoxicity against cultured P388 cells.