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Communication | Regular issue | Vol 63, No. 5, 2004, pp.1013-1016
Published online, 12th March, 2004
DOI: 10.3987/COM-04-10030
Convenient Synthesis of Pulchellalactam, a CD45 Protein Tyrosine Phosphatase Inhibitor from the Marine Fungus Corollospora pulchella, and Its Related Compounds

Jun-ichiro Bessho, Yasuhiko Shimotsu, Sachiko Mizumoto, Nobuyuki Mase, Hidemi Yoda, and Kunihiko Takabe*

*Department of Molecular Science, Faculty of Engineering, Shizuoka University, 3-5-1 Johoku, Hamamatsu 432-8561, Shizuoka, Japan


Convenient synthesis of pulchellalactam (1a) and its related compounds was accomplished. Total yields of (Z)-pulchellalactam and (E)-pulchellalactam were 55% for 5 steps and 43% for 8 steps from commercially available and inexpensive citraconic anhydride, respectively.