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Communication | Regular issue | Vol 63, No. 4, 2004, pp.785-790
Published online, 20th February, 2004
DOI: 10.3987/COM-04-10016
Synthesis of Microcarpalide, a Microfilament Disrupting Agent

Ken Ishigami and Takeshi Kitahara*

*Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan


Microcarpalide is a strong microfilament disrupting agent. The convergent and stereoselective synthesis of microcarpalide was succeeded via Julia olefination and macrolactonization.