Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 63, No. 5, 2004, pp.1057-1065
Published online, 5th March, 2004
DOI: 10.3987/COM-04-10003
KF-Alumina Immobilized in Ionic Liquids: A Novel Heterogeneous Base for Heterocyclization of Alkylsulfanylphenylamines into 1,4-Benzothiazine

Bhupender S. Chhikara, Anil K. Mishra, and Vibha Tandon*

*Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi-110 007, India


A rapid and convenient synthetic methodology for the cyclocondensative transformation of various alkylsulfanylphenylamines with bromoacetyl bromide by supporting on KF-alumina in ionic liquids [bmim][Br] and [bmim][BF4] has been developed to obtain 3-oxo-1,4-benzothiazine in good yields. The product is easily obtained by extraction with ethyl acetate and concentrating under vacuum. Easy recovery of ionic liquid and use in consecutive reactions is also reported.