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Paper | Special issue | Vol 61, No. 1, 2003, pp.449-457
Published online, 27th October, 2003
DOI: 10.3987/COM-03-S59
A New Convenient Method for Synthesis of 3-(2-Oxoethylidene)isoindolin-1-ones Employing Palladium(II) Acetate and DDQ

Akiharu Ueki, Satoru Tanaka, Masunori Kumazawa, Takashi Ooi, Shigeki Sano, and Yoshimitsu Nagao*

*Faculty of Pharmaceutical Sciences, The University of Tokushima, Sho-machi, Tokushima 770-8505, Japan

Abstract

Treatment of 2-alkyl-3-hydroxy-3-vinylisoindolin-1-ones with 10 mol % of Pd(OAc)2 and 1 mol eq. of DDQ in THF under reflux gave 3-(2-oxoethylidene)isoindolin-1-ones in 65-80% yields.