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Communication | Special issue | Vol 61, No. 1, 2003, pp.59-63
Published online, 4th August, 2003
DOI: 10.3987/COM-03-S32
Preparation and Derivatization of the Core Compound of Macrosphelide E-G Series

Yuji Matsuya, Kentaro Ishihara, Nobutaka Funamori, Takanori Kawaguchi, and Hideo Nemoto*

*Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan

Abstract

The macrosphelide core (2) possessing a skeleton of macrosphelide E-G series was newly prepared, and its oxidative derivatization was investigated. The compound (2) was found to be less reactive to oxidations compared to the epimeric core (1), and it was suggested that there is a considerable difference among their geometry-optimized conformations, which affected the reactivity.