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Communication | Special issue | Vol 61, No. 1, 2003, pp.39-43
Published online, 15th July, 2003
DOI: 10.3987/COM-03-S26
Synthesis of Various Macrosphelides by Oxidative Derivatization of the Macrosphelide Core

Yuji Matsuya, Takanori Kawaguchi, and Hideo Nemoto*

*Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan


The macrosphelide core (4), simple 16-membered trilactone, was subjected to several oxidative conditions to produce various natural macrosphelide analogues, including macrosphelides A and C. This approach provided a new access to diverse macrosphelides for a study on their structure-activity relationships.