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Note | Special issue | Vol 61, No. 1, 2003, pp.521-528
Published online, 10th June, 2003
DOI: 10.3987/COM-03-S13
An Attempt for Biaryl Coupling Reaction of Benzyl Benzoate Derivatives under Ullmann Conditions

Hitoshi Abe,* Shigemitsu Takeda, Yasuo Takeuchi, and Takashi Harayama*

*Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan

Abstract

The biaryl coupling reaction of benzyl benzoate derivatives (3) and (4) was examined with copper(0) reagent. A dimerized product (9) was mainly obtained whereas the desired intramolecularly coupled product (11) was not detected when 3 was employed as the substrate. On the other hand, the reaction of 4 afforded a small amount of the desired lactone (14) although the main product was the dimerized 12.