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Paper | Regular issue | Vol 63, No. 4, 2004, pp.819-826
Published online, 9th February, 2004
DOI: 10.3987/COM-03-9984
Synthesis of 2,3,8-Trisubstituted 7H-Isoindolo[5,6-g]quinoxaline-5,7,9,11(8H)-tetraones

Heesoon Lee,* Sungmoon Cho, Byeonggil Choi, Kwon Namgoong, and Jae-Kyung Jung

*College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea

Abstract

Oxidation of 3-methyl- or 7,8-dimethylbenzo[g]quinoxalinedione produced the unusual product, dihydroxybenezo[g]quinoxaline-5,10-dione- carboxylic acid or dicarboxylic acid. This process was used for the synthesis of a series of 2,3,8-trisubstituted isoindolo[5,6-g]quinoxalinetetraone derivatives.