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Note | Regular issue | Vol 63, No. 1, 2004, pp.95-105
Published online, 21st November, 2003
DOI: 10.3987/COM-03-9901
Synthesis of 2-Substituted 3,4-Dihydroquinazoline Derivatives via Regioselective Addition of a Carbon Nucleophile to a Carbodiimide

Bum Hoon Lee, Jae Yeol Lee,* Bong Young Chung, and Yong Sup Lee*

*Division of Life Sciences, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 131-650, Korea

Abstract

Synthesis of 2-alkyl or phenyl-substituted 3,4-dihydroquinazoline derivatives (6) is described via regioselective carbon nucleophilic addition (RMgBr and RM) to a carbodiimide (4) followed by intramolecular conjugate addition.