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Note | Regular issue | Vol 63, No. 1, 2004, pp.87 -93
Published online, 31st October, 2003
DOI: 10.3987/COM-03-9896
One-Pot Synthesis of Tetra-substituted Imidazoles on Silica Gel under Microwave Irradiation

Yu Xu, Yan-Zhi Liu, Lei Rui, Lei Liu, and Qing-Xiang Guo*

*Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, China


A new procedure for synthesis of tetra-substituted imidazoles was developed. A series of imidazole derivatives including six new compounds were synthesized by this procedure via condensation of benzoin, aromatic aldehyde, amine and ammonium acetate in the presence of silica gel under solvent-free microwave irradiation.