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Paper | Regular issue | Vol 60, No. 12, 2003, pp.2717-2725
Published online, 2nd October, 2003
DOI: 10.3987/COM-03-9894
Catalytic Hydrogenation of 8-Acyloxy-1-cyanoisoquinoline and Synthesis of 9-Methoxy-9-deethoxycribrostatin 6

Shinsuke Nakahara* and Akinori Kubo

*Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan


Catalytic hydrogenation of 8-acyloxy-1-cyanoisoquinolines (6)Å`(9) in the presence of 10% Pd-C and synthesis of 9-methoxy isomer (10) of cribrostatin 6 utilizing the compound (26) obtained by this reaction are described.