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Paper | Regular issue | Vol 60, No. 11, 2003, pp.2519-2525
Published online, 16th September, 2003
DOI: 10.3987/COM-03-9876
Synthesis of 8,9,10,11-Tetrahydroindolo[2,1-c]benzo[1,2,4]triazine. A New Ring Syntem

Paola Barraja, Patrizia Diana, Antonino Lauria, Alessandra Montalbano, Anna Maria Almerico, Gaetano Dattolo, and Girolamo Cirrincione*

*Dipartimento Farmacochimico Tossicologico e Biologico Università degli Studi di Palermo Via Archirafi 32, 90123 Palermo, Italy

Abstract

Indolo[2,1-c]benzo[1,2,4]triazine, a new ring system, was synthesized by diazotization of 2-amino-1 aryltetrahydroindoles followed by an intramolecular coupling of the diazonium group with the aryl moiety. All the new compounds were screened at the NCI for antiproliferative property but none of them showed significant activity.