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Paper | Regular issue | Vol 60, No. 12, 2003, pp.2631-2636
Published online, 9th October, 2003
DOI: 10.3987/COM-03-9867
One Pot Syntheses of Substituted Naphthyridines and 2H-Pyrano[3,2-g]quinolin-2-ones in Water

Noé Rosas,* Pankaj Sharma, Armando Cabrera, Guillermo Pénieres, José L. García, and Luis A. Maldonado

*Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitatria, Coyoacán 04510, Mexico


One pot catalytic syntheses of substituted 1,8-naphthyridines and 2H-pyrano[3,2-g]quinolin-2-ones by the reaction of α-ketoalkynes with 6-aminonicotinamide and 7-amino-4-methylcoumarin respectively in water, using a homogeneous nickel catalyst at very mild reaction conditions are described. In the absence of this catalytic system very low yields are obtained even after long reaction time.