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Paper | Regular issue | Vol 60, No. 10, 2003, pp.2241-2249
Published online, 18th August, 2003
DOI: 10.3987/COM-03-9839
Synthesis of 10-Hydroxy-3-methyl-1H-pyrano[4,3-b]quinoline Derivatives

Mieko Morone, Atsuko Sato, and Yutaka Azuma*

*Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

Abstract

Heating of 4-arylamino-3-ethoxycarbonyl-6-methyl-2H-pyran-2-one derivatives (3), which were obtained from the reaction between 4-chloro-3- ethoxycarbonyl-6-methyl-2H-pyran-2-one (2) and anilines, in PPA gave corresponding 10-hydroxy-3-methylpyrano[4,3-b]quinoline derivatives (4) and 1-(4-hydroxyquinolin-2-yl)propan-2-one (5).