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Paper | Regular issue | Vol 60, No. 11, 2003, pp.2435-2440
Published online, 16th September, 2003
DOI: 10.3987/COM-03-9837
Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones over Silica Sulfuric Acid as a Reusable Catalyst under Solvent-free Conditions

Peyman Salehi,* Minoo Dabiri, Mohammad Ali Zolfigol, and Mohammad Ali Bodaghi Fard

*Department of Phytochemistry, Aromatic and Medicinal Plants and Drug Research Institute, Shahid Beheshti University, Evin, Tehran 19835-389, Iran

Abstract

3,4-Dihydropyrimidin-2(1H)-ones and their sulfur analogues are efficiently synthesized by the three-component condensation of β-dicarbonyl compounds, aromatic and aliphatic aldehydes, and urea or thiourea in the presence of catalytic amounts of silica sulfuric acid under solvent-free conditions in high yields. The catalyst is recyclable and can be used several times without any decrease in the products yields.