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Note | Regular issue | Vol 60, No. 7, 2003, pp.1681-1688
Published online, 9th June, 2003
DOI: 10.3987/COM-03-9781
Isolation and Identification of an Unusual Impurity in an Intermediate of Rimadyl® (Carprofen)

John L. Tucker,* Keith M. DeVries, Philip D. Hammen, Peter R. Rose, Brian K. Raymer, and Diane Rescek

*Chemical Research & Development and the E.M.S. Department, Pfizer Global Research and Development, Groton, CT 06340, U.S.A.


The isolation and identification of an unknown process related impurity in a key intermediate of Rimadyl® (carprofen) is described. The structure of the unknown was evaluated by NMR spectral analysis and eventually confirmed by single crystal X-Ray. A re-slurry in warm acetic acid was found to reduce the level of the unknown to an acceptable level.