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Communication | Regular issue | Vol 60, No. 6, 2003, pp.1303-1306
Published online, 7th April, 2003
DOI: 10.3987/COM-03-9755
Spectamines A and B, Possible Inhibitors of Superoxide Anion Production of Macrophages from Cassia spectabilis

Tsunashi Kamo,* Kentaro Maehara, Kazuya Sato, and Mtsuru Hirota

*Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minami-minowa, Kami-ina, Nagano 399-4598, Japan

Abstract

Two novel piperidine alkaloids were isolated from an African legume, Cassia spectabilis, and identified as the O-benzoyl (1, named spectamine A) and O-acetyl (2, named spectamine B) derivatives of (+)-iso-6-cassine (3). The absolute configurations of 1-3 were established to be (2R,3R,6R) using the modified Mosher’s method. Compound (1) inhibited the superoxide anion production of macrophages, while it did not quench the superoxide anion which is produced by xanthine oxidase at a concentration of 25 μM.