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Paper | Regular issue | Vol 60, No. 6, 2003, pp.1339-1350
Published online, 4th April, 2003
DOI: 10.3987/COM-03-9734
Synthesis and Dopamine Receptor Binding of Some Pyrazolo[3’,4’:6,7]azepino[5,4,3-cd]indoles

Peter Gmeiner, Harald Hübner, Kayed A. Abu Safieh, Ismail I. Fasfous, Mustafa M. El-Abadelah,* Salim S. Sabri, and Wolfgang Voelter

*Chemistry Department, Faculty of Science, University of Jordan, Amman 11942, Jordan

Abstract

A synthesis of some substituted pyrazolo[3’,4’:6,7]azepino[5,4,3-cd]indoles is described and their affinities to dopamine receptors were evaluated. The tested compounds (3a-d and 4a,b) showed micromolar affinity to the bovine D1 receptor subtype and the human D2, D3 and D4 receptor isoforms.