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Paper | Regular issue | Vol 60, No. 6, 2003, pp.1329-1337
Published online, 28th April, 2003
DOI: 10.3987/COM-03-9731
Synthesis of 6-Substituted Imidazo[4,5-d]pyridazin-7-ones

Paul J. Gilligan* and Rajagopal Bakthavatchalam

*Discovery Chemistry, Bristol-Myers Squibb Co., 5 Research Parkway, Wallingford, CT 06492, U. S. A.

Abstract

A novel synthesis of 6-substituted imidazo[4,5-d]pyridazin-7-ones is described, which employs 1,2-disubstituted 4-aroylimidazole-5-carboxylates as key intermediates.