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Paper | Regular issue | Vol 60, No. 5, 2003, pp.1185-1190
Published online, 17th March, 2003
DOI: 10.3987/COM-03-9725
3-Dimethylhydrazono-1,1,1-trifluoro-2-propanone as a Useful Synthetic Equivalent of Trifluoropyruvaldehyde — Application to Synthesis of Fluorine-containing Heterocycles

Yasuhiro Kamitori*

*Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan


3-Dimethylhydrazono-1,1,1-trifluoro-2-propanone (4) which is easily obtainable from formaldehyde dimethylhydrazone and trifluoroacetic anhydride was found to be an usuful synthetic equivalent of trifluoropyruvaldehyde for the synthesis of fluorine-containing heterocycles. With the use of 4, 4-trifluoromethylimidazoles and 2-trifluoromethylquinoxaline were successfully synthesized.