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Paper | Regular issue | Vol 60, No. 5, 2003, pp.1133-1145
Published online, 10th March, 2003
DOI: 10.3987/COM-03-9716
Synthesis of Metabolites of the Prodrug 2,5-Bis(4-O-methoxyamidinophenyl)furan

Mariappan Anbazhagan, Janelle Y. Saulter, James E. Hall, and David W. Boykin*

*Department of Chemistry, Georgia State University, University Plaza, Atlanta, GA 30303, U.S.A.

Abstract

The synthesis of three metabolites of the prodrug 2,5-bis (4-O-methoxyamidinophenyl)furan (1), 2-(4-hydroxyamidinophenyl)-5-(4-meth- oxyamidinophenyl)furan (M1), 2-(4-amidinophenyl)-5-(4-ethoxyamidino- phenyl)-furan (M3) and 2-(4-amidinophenyl)- 5-(4-hydroxyamidinophenyl)furan (M4), is reported. The key step in each of the syntheses involves the Heck reaction.