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Communication | Special issue | Vol 59, No. 1, 2003, pp.51-55
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S9
Asymmetric Intramolecular Aza-Michael Reaction Using Enviromentally Friendly Organocatalysis

Kiyosei Takasu,* Soumen Maiti, and Masataka Ihara*

*Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University


This communication describes enantioselective intramolecular aza-Michael reaction to prepare 1,2,3,4-tetrahydroisoquinolines by using organocatalysts. The organocatalytic reaction offers new green chemical process in heterocyclic chemistry. Additional noting, both enantiomers of the product were easily synthesized by using two types of organocatalysts prepared from the same amino acid.