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Communication | Special issue | Vol 59, No. 2, 2003, pp.497-500
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S74
Structure Determination of Lustromycin, an Antibiotic against Anaerobic Bacteria

Masaki Handa, Hideaki Ui, Daisuke Yamamoto, Soichi Monma, Yuzuru Iwai, Toshiaki Sunazuka, and Satoshi Omura*

*Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute, Shirokane, Tokyo 108-8642, Japan


Extensive homo and heteronuclear two-dimensional NMR studies revealed lustromycin, an anti-anaerobic antibiotic. Its structure consists of a decaline ring system fused to a 10-membered macrolactone and a 14-membered macrolactone having an enol ether moiety conjugated with a maleic anhydride functionality.