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Communication | Special issue | Vol 59, No. 2, 2003, pp.485-490
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S70
■ A Stereocontrolled Synthesis of (+)-Rhopaloic Acid A Using a Dioxabicyclo[3.2.1]octane Chiral Building Block

Kohei Kadota and Kunio Ogasawara*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Utilizing a chiral building block having a dioxabicyclo[3.2.1]octane framework, (+)-rhopaloic acid A, a potent cytotoxic norsesterterpene isolated from the marine sponge Rhopaloeides sp., has been synthesized in a stereocontrolled manner.