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Communication | Special issue | Vol 59, No. 2, 2003, pp.481-484
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S68
A New Efficient Synthesis of Both Enantiomers of Macrosphelide Core: A Potential Precursor for Functionalized Macrosphelides

Yuji Matsuya, Takanori Kawaguchi, Hideo Nemoto,* Hiroshi Nozaki, and Hiroki Hamada

*Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan


The asymmetric synthesis of a macrosphelide core (1) and its enantiomer was achieved from (S)- or (R)-3-hydroxybutyrate in excellent yields. These compounds are potentially useful precursors for the preparation of biologically important macrosphelide analogues.