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Communication | Special issue | Vol 59, No. 2, 2003, pp.473-476
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S64
Synthesis of (3-Indolyl)heteroaromatics by Suzuki-Miyaura Coupling and Their Inhibitory Activity in Lipid Peroxidation

Atsushi Nishida,* Naoki Miyashita, Mihoko Fuwa, and Masako Nakagawa

*Graduate School of Pharmaceutical Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

Abstract

A variety of (3-indolyl)heteroaromatic compounds were synthesized by Suzuki-Miyaura coupling of 3-indolylboronic acid and halogenated heteroaromatics. 2-(3-Indolyl)thiophene showed potent inhibitory activity against lipid peroxidation by rat liver microsome.