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Paper | Special issue | Vol 59, No. 2, 2003, pp.587-593
Published online, 1st January, 1970
DOI: 10.3987/COM-02-S57
Synthesis and Character of New Bis(isoxazoline) Ligands

Toshio Shinohara, Kazuhiko Wakita, Midori A. Arai, Takayoshi Arai, and Hiroaki Sasai*

*The Institute of Scientific and Industrial Research, Osaka University, 8-1. Mihogaoka, Ibaraki, Osaka 567-0047, Japan


Synthesis of two kinds of new bis(isoxazoline) ligand, achiral 2,2’-bis(isoxazolinyl)propane and (R)-2,2’-bis(isoxazolinyl)-1,1’-binaphthyl bearing an axial chirality is described. Both of the bis(isoxazoline) ligands accelerated the Pd(II)-catalyzed Wacker-type cyclization of alkenyl alcohol. The isoxazoline ligands were found to be essential to promote the cyclization.